CALICHEAMICINS, A NOVEL FAMILY OF ANTITUMOR ANTIBIOTICS 3. ISOLATION, PURIFICATION AND CHARACTERIZATION OF CALICHEAMICINS β1Br, γ1Br, α2I, α3I, β1I, γ1I AND δ1I

MAY D. LEE; JOANN K. MANNING; DAVID R. WILLIAMS; NYDIA A. KUCK; RAYMOND T. TESTA; DONALD B. BORDERS

doi:10.7164/antibiotics.42.1070

CALICHEAMICINS, A NOVEL FAMILY OF ANTITUMOR ANTIBIOTICS

3. ISOLATION, PURIFICATION AND CHARACTERIZATION OF CALICHEAMICINS β₁^Br, γ₁^Br, α₂^I, α₃^I, β₁^I, γ₁^I AND δ₁^I

MAY D. LEE, JOANN K. MANNING, DAVID R. WILLIAMS, NYDIA A. KUCK, RAYMOND T. TESTA, DONALD B. BORDERS

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 7 Pages 1070-1087

DOI https://doi.org/10.7164/antibiotics.42.1070

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Abstract

Novel antitumor antibiotics, calicheamicins β₁^Br, γ₁^Br, α₂^I, α₃^I, β₁^I, γ₁^I and δ₁^I were recovered from the fermentation broth of Micromonospora echinospora ssp. calichensis by solvent extraction, selective precipitation, normal phase, reversed phase and partition chromatography. The individual components were characterized by their UV, IR, ¹H and ¹³C NMR spectral data.

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