METABOLIC PRODUCTS OF MICROORGANISMS. 254 STRUCTURE OF THE NEW NIKKOMYCINS PSEUDO-Z AND PSEUDO-J

HOLGER HEITSCH; WILFRIED A. KÖNIG; HEINRICH DECKER; CHRISTIANE BORMANN; HANS-PETER FIEDLER; HANS ZÄHNER

doi:10.7164/antibiotics.42.711

METABOLIC PRODUCTS OF MICROORGANISMS. 254

STRUCTURE OF THE NEW NIKKOMYCINS PSEUDO-Z AND PSEUDO-J

HOLGER HEITSCH, WILFRIED A. KÖNIG, HEINRICH DECKER, CHRISTIANE BORMANN, HANS-PETER FIEDLER, HANS ZÄHNER

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 5 Pages 711-717

DOI https://doi.org/10.7164/antibiotics.42.711

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Abstract

Two new nikkomycins were isolated from the fermentation broth of Streptomyces tendae Tü 901/PF 53⁺-3. These new metabolites, nikkomycins pseudo-Z (ψZ, 1) and pseudo-J (ψ-J, 2) differ from the corresponding nikkomycins Z and J by a C-glycosidic bond between C-5 of uracil and C-1' of 5-amino-5-deoxy-D-allo-furanuronic acid instead of an N-lycosidic bond. The structure elucidation was achieved by two-dimensional NMR techniques and mass spectrometry.

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