METABOLIC PRODUCTS OF MICROORGANISMS. 255 NIKKOMYCINS Wz AND Wx, NEW CHITIN SYNTHETASE INHIBITORS FROM STREPTOMYCES TENDAE

HEINRICH DECKER; FRANZ WALZ; CHRISTIANE BORMANN; HANS ZÄHNER; HANS-PETER FIEDLER; HOLGER HEITSCH; WILFRIED A. KÖNIG

doi:10.7164/antibiotics.43.43

METABOLIC PRODUCTS OF MICROORGANISMS. 255

NIKKOMYCINS W_z AND W_x, NEW CHITIN SYNTHETASE INHIBITORS FROM STREPTOMYCES TENDAE

HEINRICH DECKER, FRANZ WALZ, CHRISTIANE BORMANN, HANS ZÄHNER, HANS-PETER FIEDLER, HOLGER HEITSCH, WILFRIED A. KÖNIG

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 1 Pages 43-48

DOI https://doi.org/10.7164/antibiotics.43.43

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Abstract

Two new dipeptidyl nikkomycins of the Z and X type were isolated from the culture broth of Streptomyces tendae TÜ 901/395-11/32 and characterized. They show a variation in the amino acid moiety of the molecule. Nikkomycin W_z is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to uracil, whereas nikkomycin W_x is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to 4-formyl-4-imidazolin-2-one. The new nikkomycins are good inhibitors of chitin synthetase from Coprinus cinereus but they did not inhibit growth of fungi and yeasts.

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