The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
METABOLIC PRODUCTS OF MICROORGANISMS. 258
ENZYMATIC BROMINATION OF NIKKOMYCIN Z
HEINRICH DECKER, UWE PFEFFERLE, CHRISTIANE BORMANN, HANS ZÄHNER, HANS-PETER FIEDLER, KARL-HEINZ VAN PÉE, MATTHIAS RIECK, WILFRIED A. KÖNIG
Author information
JOURNAL FREE ACCESS

1991 Volume 44 Issue 6 Pages 626-634

Details
Abstract

Two brominated nikkomycins were produced by enzymatic halogenation of nikkomycin Z in the presence of a nonheme bromoperoxidase isolated from Streptomyces aureofaciens Tü 24. The monobrominated and dibrominated nikkomycin Z derivatives were substituted at the hydroxypyridyl moiety of the N-terminal amino acid of nikkomycin Z at position C-6''' (ZBr) or C-4''' and C-6''' (ZBr2).
The brominated nikkomycin Z derivatives had a decreased affinity to chitin synthase of Coprinus cinereus as compared to nikkomycin Z and exhibited a low inhibitory activity towards various fungi and yeasts.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

The Journal of Antibiotics, Series A

Share this page
feedback
 Top