A NEW ANTITUMOR SUBSTANCE, BE-13793C, PRODUCED BY A STREPTOMYCETE TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITY

KATSUHISA KOJIRI; HISAO KONDO; TOMOKO YOSHINARI; HIROHARU ARAKAWA; SHIGERU NAKAJIMA; FUMIO SATOH; KENJI KAWAMURA; AKIRA OKURA; HIROYUKI SUDA; MASANORI OKANISHI

doi:10.7164/antibiotics.44.723

A NEW ANTITUMOR SUBSTANCE, BE-13793C, PRODUCED BY A STREPTOMYCETE

TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITY

KATSUHISA KOJIRI, HISAO KONDO, TOMOKO YOSHINARI, HIROHARU ARAKAWA, SHIGERU NAKAJIMA, FUMIO SATOH, KENJI KAWAMURA, AKIRA OKURA, HIROYUKI SUDA, MASANORI OKANISHI

Author information

KATSUHISA KOJIRI
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
HISAO KONDO
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
TOMOKO YOSHINARI
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
HIROHARU ARAKAWA
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
SHIGERU NAKAJIMA
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
FUMIO SATOH
Okazaki Research Laboratories, Banyu Pharmaceutical Co., Ltd.
KENJI KAWAMURA
Okazaki Research Laboratories, Banyu Pharmaceutical Co., Ltd.
AKIRA OKURA
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
HIROYUKI SUDA
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.
MASANORI OKANISHI
Exploratory Research, † Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

1991 Volume 44 Issue 7 Pages 723-728

DOI https://doi.org/10.7164/antibiotics.44.723

Details

Abstract

A new antitumor substance, BE-13793C, which has topoisomerase inhibitory activity was isolated from the culture broth of a strain of actinomycetes. The producing strain, BA13793, isolated from a soil sample collected in Seto, Aichi Prefecture, Japan, had a resemblance to Streptoverticillium mobaraense. The active principle was extracted from the mycelium of strain BA 13793 with methanol and purified by Sephadex LH-20 column chromatography. BE-13793C showed strong inhibitory activity against topoisomerases I and II and inhibited the growth of doxorubicin-resistant or vincristine-resistant P388 murine leukemia cell lines, as well as their parent P388 cell line.

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