The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
DACTYLOCYCLINES, NOVEL TETRACYCLINE DERIVATIVES PRODUCED BY A Dactylosporangium sp.
I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY
J. SCOTT WELLSJOSEPH O'SULLIVANCAROL AKLONISHELEN A. AXADRIENNE A. TYMIAKDONALD R. KIRSCHWILLIAM H. TREJOPACIFICO PRINCIPE
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1992 Volume 45 Issue 12 Pages 1892-1898

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Abstract

A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occuring tetracycline C2 amides which lack cross resistance with tetracycline.

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© Japan Antibiotics Research Association
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