SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE CHAIN

TAKAAKI OKITA; KIYOTO IMAE; TOSHIFUMI HASEGAWA; SEIJI IIMURA; SHINJI MASUYOSHI; HAJIME KAMACHI; HIDEO KAMEI

doi:10.7164/antibiotics.46.833

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE CHAIN

TAKAAKI OKITA, KIYOTO IMAE, TOSHIFUMI HASEGAWA, SEIJI IIMURA, SHINJI MASUYOSHI, HAJIME KAMACHI, HIDEO KAMEI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 5 Pages 833-839

DOI https://doi.org/10.7164/antibiotics.46.833

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Abstract

Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-l-propen-l-yl]cephalosporin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia.

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