WF11899A, B AND C, NOVEL ANTIFUNGAL LIPOPEPTIDES I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

TOSHIRO IWAMOTO; AKIHIKO FUJIE; KAZUTOSHI SAKAMOTO; YASUHISA TSURUMI; NOBUHARU SHIGEMATSU; MICHIO YAMASHITA; SEIJI HASHIMOTO; MASAKUNI OKUHARA; MASANOBU KOHSAKA

doi:10.7164/antibiotics.47.1084

WF11899A, B AND C, NOVEL ANTIFUNGAL LIPOPEPTIDES

I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

TOSHIRO IWAMOTO, AKIHIKO FUJIE, KAZUTOSHI SAKAMOTO, YASUHISA TSURUMI, NOBUHARU SHIGEMATSU, MICHIO YAMASHITA, SEIJI HASHIMOTO, MASAKUNI OKUHARA, MASANOBU KOHSAKA

Author information

TOSHIRO IWAMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
AKIHIKO FUJIE
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KAZUTOSHI SAKAMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
YASUHISA TSURUMI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
NOBUHARU SHIGEMATSU
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MICHIO YAMASHITA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
SEIJI HASHIMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASAKUNI OKUHARA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASANOBU KOHSAKA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

1994 Volume 47 Issue 10 Pages 1084-1091

DOI https://doi.org/10.7164/antibiotics.47.1084

Details

Abstract

WF 11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899. These compounds belong to the echinocandin type of lipopeptides. Of these compounds, WF11899 A showed good solubility in water. These three antibiotics possess potent in vitro antifungal activities against Candida spp.

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