Disorazol A, an Efficient Inhibitor of Eukaryotic Organisms Isolated from Myxobacteria
1995 Volume 48 Issue 1 Pages 31-35
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1995 Volume 48 Issue 1 Pages 31-35
A new antibiotic, disorazol, was isolated from the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 12. It is a macrocyclic compound containing two oxazole rings. The antibiotic acted against many fungi and mammalian cell cultures. The latter responded to extremely low doses (MIC 3-30pg/ml). None of the tested bacteria and yeasts were inhibited.
