Kanchanamycins, New Polyol Macrolide Antibiotics Produced by Streptomyces olivaceus Tü 4018 I. Taxonomy, Fermentation, Isolation and Biological Activities

HANS-PETER FIEDLER; MULUGETA NEGA; CHRISTOPH PFEFFERLE; INGRID GROTH; CHRISTOPH KEMPTER; HOLGER STEPHAN; JÖRG W. METZGER

doi:10.7164/antibiotics.49.758

Kanchanamycins, New Polyol Macrolide Antibiotics Produced by Streptomyces olivaceus Tü 4018

I. Taxonomy, Fermentation, Isolation and Biological Activities

HANS-PETER FIEDLER, MULUGETA NEGA, CHRISTOPH PFEFFERLE, INGRID GROTH, CHRISTOPH KEMPTER, HOLGER STEPHAN, JÖRG W. METZGER

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 8 Pages 758-764

DOI https://doi.org/10.7164/antibiotics.49.758

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Abstract

The kanchanamycins, a group of novel 36-membered polyol macrolide antibiotics were detected in the culture filtrate and mycelium of Streptomyces olivaceus Tü 4018 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibacterial and antifungal activities, and are especially effective against Pseudomonas fluorescens. Besides the kanchanamycin complex, strain Tü 4018 produces the 42-membered macrolactones, oasomycin A and desertomycin A, as well as tryptophan-dehydrobutyrine diketopiperazine and daidzein.

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