The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Determination of Absolute Configuration and Biological Activity of New Immunosuppressants, Mycestericins D, E, F and G
TETSURO FUJITA, NORIMITSU HAMAMICHI, MASATOSHI KIUCHI, TOHRU MATSUZAKI, YUKI KITAO, KENICHIRO INOUE, RYOJI HIROSE, MASAHIKO YONETA, SHIGEO SASAKI, KENJI CHBA
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1996 Volume 49 Issue 9 Pages 846-853

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Abstract

Mycestericins D, E, F and G were isolated from the culture broth of Mycelia sterilia ATCC 20349 as potent immunosuppressants. Mycestericins F and G were identical with dihydromycestericins D and E, respectively. Their absolute configurations were determined by use of the modified MOSHER'S method and by comparison of the CD spectra of their benzoate derivatives with those of synthetic analogs. Mycestericins D, E, F and G suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction.

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The Journal of Antibiotics, Series A

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