Isolation and Structure of an Antimitotic Cyclic Peptide, Ustiloxin F: Chemical Interrelation with a Homologous Peptide, Ustiloxin B

YUKIKO KOISO; NAOKO MORISAKI; YUKIKO YAMASHITA; YUKIKO MITSUI; RYUICHI SHIRAI; YUICHI HASHIMOTO; SHIGEO IWASAKI

doi:10.7164/antibiotics.51.418

Isolation and Structure of an Antimitotic Cyclic Peptide, Ustiloxin F:

Chemical Interrelation with a Homologous Peptide, Ustiloxin B

YUKIKO KOISO, NAOKO MORISAKI, YUKIKO YAMASHITA, YUKIKO MITSUI, RYUICHI SHIRAI, YUICHI HASHIMOTO, SHIGEO IWASAKI

Author information

JOURNAL FREE ACCESS

1998 Volume 51 Issue 4 Pages 418-422

DOI https://doi.org/10.7164/antibiotics.51.418

Details

Abstract

Ustiloxin F, a microtubule inhibitor, was isolated as a minor metabolite of Ustilaginoidea virens. The structure was determined from the spectral data and by chemical interrelation to ustiloxin B through reductive removal of the sulfoxide-containing side chain of ustiloxin B to give ustiloxin F. Ustiloxin F inhibited microtubule assembly with an IC₅₀ value of 10.3 μM.

Corresponding author

Register with J-STAGE for free!