Spirofungin, a New Antifungal Antibiotic from Streptomyces violaceusniger Tü 4113

ALEXANDRA HÖLTZEL; CHRISTOPH KEMPTER; JÖRG W. METZGER; GÜNTHER JUNG; INGRID GROTH; THOMAS FRITZ; HANS-PETER FIEDLER

doi:10.7164/antibiotics.51.699

Spirofungin, a New Antifungal Antibiotic from Streptomyces violaceusniger Tü 4113

ALEXANDRA HÖLTZEL, CHRISTOPH KEMPTER, JÖRG W. METZGER, GÜNTHER JUNG, INGRID GROTH, THOMAS FRITZ, HANS-PETER FIEDLER

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JOURNAL FREE ACCESS

1998 Volume 51 Issue 8 Pages 699-707

DOI https://doi.org/10.7164/antibiotics.51.699

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Abstract

A new secondary metabolite was detected in the culture filtrate and extracts of Streptomyces violaceusniger Tü 4113 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compound named spirofungin has a polyketide-spiroketal structure and shows various antifungal activities, particularly against yeasts.

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