The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Scyphostatin, a Neutral Sphingomyelinase Inhibitor from a Discomycete, Trichopeziza mollissima: Taxonomy of the Producing Organism, Fermentation, Isolation, and Physico-chemical Properties
FUTOSHI NARAMASAHIRO TANAKATSUYOSHI HOSOYAKEIKO SUZUKI-KONAGAITAKESHI OGITA
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1999 Volume 52 Issue 6 Pages 525-530

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Abstract

We performed experiments to screen for neutral sphingomyelinase inhibitors using rat brain microsomes as an enzyme source. Among more than 10, 000 microbial extracts tested, a mycelial extract of Trichopeziza mollissima SANK 13892 exhibited potent inhibitory activity. The active compound, scyphostatin, was purified by a series of chromatographies. Scyphostatin inhibited the enzyme with an IC50 value of 1.0 μM.

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© Japan Antibiotics Research Association
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