The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Antiviral and Hemolytic Activities of Surfactin Isoforms and Their Methyl Ester Derivatives
MAREN KRACHTHARTMUT ROKOSMUHSIN ÖZELMARTIN KOWALLGEORG PAULIJOACHIM VATER
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1999 Volume 52 Issue 7 Pages 613-619

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Abstract

Inactivation of enveloped viruses (VSV SFV and SHV-1) by surfactin lipopeptides was dependent on the hydrophobicity, i.e. the number of carbon atoms of the fatty acid, and on the charge of the peptide moiety as well as on the virus species. Surfactins with fatty acid chains of 13 carbon atoms showed very low antiviral activity in comparison to C14 arid C15 isoforms. C15 surfactin monomethyl ester also inactivated SFV which was resistant to the mixture of surfactin isoforms as produced by Bacillus subtilis. In contrast, the dimethyl ester showed no virus-inactivation capacity. Disintegration of viral structures as determined by electron microscopy after inactivation of VSV and SFV was comparable to the liter reduction. The effect of the surfactin isoforms and methyl esters on erythrocyte hemolysis correlated with the virus-inactivation capacity. Surfactins with a fatty acid chain moiety of 15 carbon atoms and one negative charge showed the highest antiviral activity.

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© Japan Antibiotics Research Association
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