SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp. I. Fermentation, Isolation and Properties

ANNA L STEFANSKA; NIGEL J. COATES; LUCY M. MENSAH; ANDREW J. POPE; SARAH J. READY; STEPHEN. R. WARR

doi:10.7164/antibiotics.53.345

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp.

I. Fermentation, Isolation and Properties

ANNA L STEFANSKA, NIGEL J. COATES, LUCY M. MENSAH, ANDREW J. POPE, SARAH J. READY, STEPHEN. R. WARR

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 4 Pages 345-350

DOI https://doi.org/10.7164/antibiotics.53.345

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Abstract

A novel, potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, designated SB-219383 has been isolated from Micromonospora sp. NCIMB 40684. The fermentation, isolation and some properties are described, whilst the structure determination is described in the succeeding paper¹⁾. SB-219383 showed competitive, inhibitory activity against a Staphylococcus tyrosyl tRNA synthetase, with an IC₅₀ of <1nM, and exhibited weak in vitro activity against some Streptococcus sp.

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