Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tü 6040 I. Taxonomy, Fermentation, Isolation and Biological Activities

JUDITH SCHIMANA; HANS-PETER FIEDLER; INGRID GROTH; RODERICK SUBMUTH; WINFRIED BEIL; MARTINA WALKER; AXEL ZEECK

doi:10.7164/antibiotics.53.779

Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tü 6040

I. Taxonomy, Fermentation, Isolation and Biological Activities

JUDITH SCHIMANA, HANS-PETER FIEDLER, INGRID GROTH, RODERICK SUBMUTH, WINFRIED BEIL, MARTINA WALKER, AXEL ZEECK

Author information

JOURNAL FREE ACCESS

2000 Volume 53 Issue 8 Pages 779-787

DOI https://doi.org/10.7164/antibiotics.53.779

Details

Abstract

Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HFLC-diode-array and HPLCelectrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.

Corresponding author

Register with J-STAGE for free!