The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
CJ-15, 696 and Its Analogs, New Furopyridine Antibiotics from the Fungus Cladobotryum varium: Fermentation, Isolation, Structural Elucidation, Biotransformation and Antibacterial Activities
SHINICHI SAKEMI, JON BORDNER, DEBRA L. DECOSTA, KOEN A. DEKKER, HIDEO HIRAI, TAISUKE INAGAKI, YOON-JEONG KIM, NAKAO KOJIMA, JEFFREY C. SIMS, YUTAKA SUGIE, AKEMI SUGIURA, JOYCE A. SUTCLIFFE, KIYOSHI TACHIKAWA, SUSAN J. TRUESDELL, JOHN W. WONG, NOBUJI YOSHIKAWA, YASUHIRO KOJIMA
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2002 Volume 55 Issue 1 Pages 6-18

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Abstract

CJ-15, 696 and 7 novel furopyridine antibiotics were isolated from the fungus Cladobotryum varium CL12284. Their structures were determined by X-ray crystallography and spectral analysis. Three biotransformed analogs were also prepared from CJ-15, 696. CJ-15, 696 showed moderate activity against various Gram-positive bacteria including some drug resistant strains such as methicillin resistant Staphylococcus aureus (MRSA).

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The Journal of Antibiotics, Series A

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