N(2)-Substituted D, L-Cycloserine Derivatives
Synthesis and Evaluation as Alanine Racemase Inhibitors
2003 Volume 56 Issue 2 Pages 160-168
Details
2003 Volume 56 Issue 2 Pages 160-168
A select series of N(2)-substituted D, L-cycloserine derivatives were prepared and evaluated for inhibitory activity against purified alanine racemases (alr gene product) from Escherichia coli, Staphylococcus aureus, and Mycobacterium tuberculosis, as well as in a growth inhibition assay. N(2)-Modification led to loss of enzymatic inhibitory activity in most cases consistent with a recent proposal for cycloserine function.
