EI-1941-1 and-2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941 I. Biochemical Characterization of EI-1941-1 and-2

FUMITO KOIZUMI; YUZURU MATSUDA; SATOSHI NAKANISHI

doi:10.7164/antibiotics.56.464

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

EI-1941-1 and-2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941

I. Biochemical Characterization of EI-1941-1 and-2

FUMITO KOIZUMI, YUZURU MATSUDA, SATOSHI NAKANISHI

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 5 Pages 464-469

DOI https://doi.org/10.7164/antibiotics.56.464

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Abstract

EI-1941-1 and -2 isolated from the culture broths of Farrowia sp. selectively inhibited the human recombinant ICE activity with IC₅₀ values of 0.086 and 0.006μM, respectively, without inhibiting elastase and cathepsin B. EI-1941-1 and -2 also inhibited mature interleukin-1β secretion from THP-1 cells induced by LPS with IC₅₀ values of 5.0 and 10.3μM, respectively. Biochemical characterizations of EI-1941-1 and-2 are described in this article.

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