The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Abyssomicins, Inhibitors of the para-Aminobenzoic Acid Pathway Produced by the Marine Verrucosispora Strain AB-18-032
JULIA RIEDLINGERANDREAS REICKEHANS ZÄHNERBERNHARD KRISMERALAN T. BULLLUIS A. MALDONADOALAN C. WARDMICHAEL GOODFELLOWBOJAN BISTERDANIEL BISCHOFFRODERICH D. SÜSSMUTHHANS-PETER FIEDLER
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2004 Volume 57 Issue 4 Pages 271-279

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Abstract

A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against Gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.

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