Stimulation of Nerve Growth Factor Production by Pyrroloquinoline Quinone and Its Derivatives in Vitro and in Vivo

Kohji Yamaguchi; Akeri Sasano; Teizi Urakami; Tomoko Tsuji; Kiyosi Kondo

doi:10.1271/bbb.57.1231

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Stimulation of Nerve Growth Factor Production by Pyrroloquinoline Quinone and Its Derivatives in Vitro and in Vivo

Kohji Yamaguchi, Akeri Sasano, Teizi Urakami, Tomoko Tsuji, Kiyosi Kondo

Author information

JOURNAL FREE ACCESS

1993 Volume 57 Issue 7 Pages 1231-1233

DOI https://doi.org/10.1271/bbb.57.1231

Details

Abstract

Pyrroloquinoline quinone (PQQ), which is a cofactor of microbial quinoprotein enzymes, was found to be a potent enhancer of nerve growth factor (NGF) production in vitro. One of PQQ derivatives, oxazopyrroloquinoline trimethylester, had little activity in vitro, but increased the NGF content in rat brain in vivo.

Content from these authors

This article cannot obtain the latest cited-by information.

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!