Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Boromycin, an Anti-HIV Antibiotic
Jun KOHNOTakuya KAWAHATAToru OTAKEMotoko MORIMOTOHaruyo MORINoboru UEBAMaki NISHIOAkio KINUMAKISaburo KOMATSUBARAKeisuke KAWASHIMA
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Keywords: boromycin, anti-HIV
JOURNAL FREE ACCESS

1996 Volume 60 Issue 6 Pages 1036-1037

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Abstract

The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments. The mechanism for the anti-HIV activity of boromycin is suggested to involve blocking the later stage of HIV infection, and probably the maturity step for replication of the HIV molecule.

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