The Journal of Biochemistry
Online ISSN : 1756-2651
Print ISSN : 0021-924X
A New Low Density Lipoprotein Receptor Related Protein, LRP5, Is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E
Dong-Ho Kim, Yousuke Inagaki, Takashi Suzuki, Ryoichi X. Ioka, Shiroh Z. Yoshioka, Kenta Magoori, Man-Jong Kang, Yuko Cho, Akira Z. Nakano, Qiong Liu, Takahiro Fujino, Hiroyuki Suzuki, Hironobu Sasano, Tokuo T. Yamamoto
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Keywords: apoE, LDL receptor family, LDL receptor-related protein, lipoprotein
JOURNAL FREE ACCESS

1998 Volume 124 Issue 6 Pages 1072-1076

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Abstract

The isolation and characterization of rabbit and human cDNAs revealed a new low density lipoprotein receptor (LDLR)-related protein (LRP) designated as LRP5. Human LRP5 cDNA encodes a 1, 616-amino acid type I membrane-like protein with three ligand binding repeats in its extracellular region. LDLR-deficient cells transduced by recombinant adenovirus containing human LRP5 exhibited increased binding of apolipoprotein E (apoE)-enriched β-migrating very low density lipoprotein. Northern blotting and in situ hybridization revealed a high level of LRP5 expression in hepatocytes and the adrenal gland cortex. In LDLR-deficient Watanabe heritable hyperlipidemic rabbits, LRP5 mRNA was increased in the liver and accumulated in cholesterol-laden foam cells of atherosclerotic lesions.

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© The Japanese Biochemical Society
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