The Journal of Biochemistry
Online ISSN : 1756-2651
Print ISSN : 0021-924X
Human Histone Deacetylase SIRT 2 Interacts with the Homeobox Transcription Factor HOXA 10
Nancy S. BaeMark J. SwansonAlex VassilevBruce H. Howard
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Keywords: HOXA10, SIRT2
JOURNAL FREE ACCESS

2004 Volume 135 Issue 6 Pages 695-700

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Abstract

Histone deacetylases are required for transcriptional repression in eukaryotes. Saccharomyces cerevisiae has several histone deacetylases, of which ySir2p is the most conserved throughout evolution. Currently, there is no report on the interacting protein partner of a human Sir2 homolog, SIRT 2. Here we show for the first time that SIRT 2 interacts with the homeobox transcription factor, HOXA 10, which was identified in a two-hybrid screen. Interactions were confirmed by co-immunoprecipitation from in vitro translations as well as in human cell-free extracts. Taken together with mouse knockout studies, our results raise the intriguing possibility that SIRT 2 plays a role in mammalian development.

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