The Journal of Biochemistry
Online ISSN : 1756-2651
Print ISSN : 0021-924X
Synthesis of Pyridinoline during In Vitro Aging of Bone Collagen
Akiyoshi UCHIYAMATetsuo INOUEDaisaburo FUJIMOTO
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JOURNAL FREE ACCESS

1981 Volume 90 Issue 6 Pages 1795-1798

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Abstract

Pyridinoline is a non-reducible crosslink of collagen. The changes in the content of this crosslink during in vitro aging of bone collagen were studied. The pyridinoline content of bone collagen of 6-week-old chick was very low. When the collagen was incubated with physiological saline in air at 37°C, the pyridinoline content increased markedly. After 6 weeks, the content reached the same level as that of the adult. The synthesis of pyridinoline was inhibited when air was excluded. The in vitro aged collagen was less susceptible to pepsin than the untreated collagen. The results indicate that pyridinoline is one of the mature crosslinks of collagen and plays a role in the stabilization of collagen fibers.

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© The Japanese Biochemical Society
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