Drug Metabolism and Pharmacokinetics
Print ISSN : 0916-1139
DETERMINATION OF VALPROIC ACID IN TEAR BY GCQ -ASSESSEMENT OF THE CONCENTRATIONS OF DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM IN TEAR-
Masaharu NAKAJIMA, Tomoko OHTA, Nozomi KAWAKAMI, Susumu YAMATO, Kenji SHIMADA, Hiroshi MIYAZAKI, Akira HONDA, Jiro MIYAMOTO, Junichi SHODA, Hiromi YOSIIIOKA, Sato YAKUSHI, Masayuki OHYA
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1998 Volume 13 Issue supplement Pages 120-121

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Abstract

The concentrations of sodium valproate (VPA) in tear and plasma by a quadrapole ion trap type GC/MS (GCQ) in a negative ion/chemical ionization/electroncapture mode. VPA was converted into the pentafluorobenzyl ester and was quantified by monitoring the ion of m/z 143. The VPA concentrations [C]Ts in the tear obtained from patients by non-invasive Schirmer method correlated very well with those of the unbound form in the plasma, indicating that the [C]TS will be used as a convenient index for monitoring the unbound VPA level in the patients.

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