Cardiac Performance and Coenzyme Q10 in Thyroid Disorders

HITOSHI SUZUKI; TAKESHI NAITOH; SUMIO KUNIYOSHI; NOBUYUKI BANBA; HISAMOTO KURODA; YOSHINOBU SUZUKI; MASAKI HIRAIWA; NORIKO YAMAZAKI; MAKOTO ISHIKAWA; YOSHIHISA HASHIGAMI; NORIO KASE; HIROHUMI KOBORI; KIKUO KASAI; SHIN-ICHI SHIMODA

doi:10.1507/endocrj1954.31.755

HITOSHI SUZUKI, TAKESHI NAITOH, SUMIO KUNIYOSHI, NOBUYUKI BANBA, HISAMOTO KURODA, YOSHINOBU SUZUKI, MASAKI HIRAIWA, NORIKO YAMAZAKI, MAKOTO ISHIKAWA, YOSHIHISA HASHIGAMI, NORIO KASE, HIROHUMI KOBORI, KIKUO KASAI, SHIN-ICHI SHIMODA

Author information

HITOSHI SUZUKI
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
TAKESHI NAITOH
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
SUMIO KUNIYOSHI
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
NOBUYUKI BANBA
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
HISAMOTO KURODA
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
YOSHINOBU SUZUKI
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
MASAKI HIRAIWA
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
NORIKO YAMAZAKI
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
MAKOTO ISHIKAWA
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
YOSHIHISA HASHIGAMI
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
NORIO KASE
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
HIROHUMI KOBORI
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
KIKUO KASAI
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine
SHIN-ICHI SHIMODA
Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine

JOURNAL FREE ACCESS

1984 Volume 31 Issue 6 Pages 755-761

DOI https://doi.org/10.1507/endocrj1954.31.755

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Abstract

To investigate the relationship between serum levels of Coenzyme Q10 and cardiac performance in thyroid disorders, we studied the cardiac performance and assessed serum levels of thyroid hormones and Coenzyme Q10 in 20 patients with hyperthyroidism, 5 patients with hypothyroidism and 10 normal subjects. A significant inverse correlation between thyroid hormones and Coenzyme Q10 levels was found by performing partial correlation analysis. Because low serum levels of Coenzyme Q10 were found in thyrotoxic patients and congestive heart failure may occur as a result of severe hyperthyroidism, 120mg of Coenzyme Q10 was administered daily for one week to 12 hyperthyroid patients and the change in cardiac performance was assessed. Further augmentation of cardiac performance was found in hyperthyroid hearts, which were already augmented, after the administration of Coenzyme Q10. It appears, therefore, that the Coenzyme Q10 dose actually has a therapeutic value for congestive heart failure induced by severe thyrotoxicosis.

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