Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Abdominal Vagotomy Decreased the Number of Ova Shed and Serum Progesterone Levels on Estrus in the Cyclic Hamster
YASUHIKO NAKAMURAHIROSHI KATOPAUL F. TERRANOVA
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1992 Volume 39 Issue 1 Pages 141-145

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Abstract

The effects of abdominal vagotomy (AVGT) on ovarian function were studied in cyclic hamsters. AVGT significantly decreased the number of ova shed (AVGT: 10.5±1.5 ova/hamster, sham: 15.8±0.7 ova/hamster; P<0.05) and serum progesterone levels (AVGT: 2.1±0.3ng/ml, sham: 3.9±0.7ng/ml; P<0.05) on the morning of estrus. However, progesterone concentrations in the corpora lutea and non-luteal ovary on estrus in the AVGT and sham groups were similar. The serum estradiol levels in both groups on proestrus increased from 0900h (AVGT: 75±10pg/ml, sham: 72±6pg/ml) to 1500h (AVGT: 204±27pg/ml, sham: 196±35pg/ml) but there was no significant difference between the two groups. Partial degranulation of ovarian mast cells was not increased in the AVGT group. Also, vasoactive intestinal peptide (VIP) content in the ovary was not increased by AVGT at 0900h on proestrus (AVGT: 60.1±16.8pg/ovary, sham: 37.2±14.3pg/ovary). These results indicated that AVGT interferes with normal ovulation and results in an increase in the number of atretic follicles, but that these effects by AVGT seemed not to be mediated through ovarian mast cells and VIP.

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© The Japan Endocrine Society
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