Cushing's Disease Associated with Adrenal Myelolipoma, Adrenal Calcification and Thyroid Cancer

MITSUAKI YOSHIOKA; KATSUYA FUJIMORI; MINAKO WAKASUGI; NOBUYASU YAMAZAKI; MIZUO KUROKI; TADASHI TSUCHIDA; HIROSHI SEKI; MASAO SEKIYA; TETSURO TAMURA

doi:10.1507/endocrj.41.461

MITSUAKI YOSHIOKA, KATSUYA FUJIMORI, MINAKO WAKASUGI, NOBUYASU YAMAZAKI, MIZUO KUROKI, TADASHI TSUCHIDA, HIROSHI SEKI, MASAO SEKIYA, TETSURO TAMURA

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MITSUAKI YOSHIOKA
Departments of Internal Medicine, Niigata Prefectural Central Hospital
KATSUYA FUJIMORI
Departments of Internal Medicine, Niigata Prefectural Central Hospital
MINAKO WAKASUGI
Departments of Internal Medicine, Niigata Prefectural Central Hospital
NOBUYASU YAMAZAKI
Departments of Surgery, Niigata Prefectural Central Hospital
MIZUO KUROKI
Departments of Neurosurgery, Niigata Prefectural Central Hospital
TADASHI TSUCHIDA
Departments of Neurosurgery, Niigata Prefectural Central Hospital
HIROSHI SEKI
Departments of Radiology, Niigata Prefectural Central Hospital
MASAO SEKIYA
Departments of pathology, Niigata Prefectural Central Hospital
TETSURO TAMURA
Department of Neurosurgery, Niigata University School of Medicine

Keywords: Cushing's disease, Adrenal myelolipoma, Adrenal calcification, Thyroid cancer

JOURNAL FREE ACCESS

1994 Volume 41 Issue 4 Pages 461-466

DOI https://doi.org/10.1507/endocrj.41.461

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Abstract

A 51-year-old woman with Cushing's disease associated with adrenal myelolipoma is reported. A further characteristic feature was the coexistence of bilateral adrenal calcification and thyroid cancer. Previously several cases of adrenal myelolipoma associated with endocrine dysfunction were reported. The combination of Cushing's disease and adrenal myelolipoma has only been described in two cases of recurrent Cushing's disease but never in an initial occurrence of Cushing's disease. Continued stimulation by excessive adrenocorticotropic hormone (ACTH) not only developed adrenal hyperplasia but also might be involved in the pathogenesis of adrenal myelolipoma.

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