Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
Assessment of Insulin Resistance in Acromegaly Associated with Diabetes Mellitus before and after Transsphenoidal Adenomectomy
TARO WASADA, KAORI AOKI, AKIKO SATO, KOZO KATSUMORI, KAZUKO MUTO, OSAMU TOMONAGA, HIROKI YOKOYAMA, NAOKO IWASAKI, TETSUYA BABAZONO, CHIEKO TAKAHASHI, YASUHIKO IWAMOTO, YASUE OMORI, NAOMI HIZUKA
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Keywords: Acromegaly, Adenomectomy, IGF-1, Insulin resistance
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1997 Volume 44 Issue 4 Pages 617-620

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Abstract

With a euglycemic hyperinsulinemic clamp method, whole-body insulin resistance was assessed in 6 cases with acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. The glucose infusion rate (GIR) correlated well with the plasma IGF-I level but poorly with that of GH. Further improvement in insulin sensitivity occurred 3-4 months after operation without substantial changes in plasma levels of both GH and IGF-I or glycemic control. These results indicate that GH excess can induce insulin resistance in association with plasma IGF-1 and also through undefined secondary effect.

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