Pulmonary Infiltrates with Eosinophilia due to Naproxen

Haruhiko OGAWA; Kazuyoshi KURASHIMA; Masanobu NAMURA; Hounin KANAYA; Youichi KAWAMURA; Takio OHKA; Hiroshi KURUMAYA; Masahide YASUI; Masaki FUJIMURA; Tamotsu MATSUDA

doi:10.2169/internalmedicine1962.30.32

Haruhiko OGAWA, Kazuyoshi KURASHIMA, Masanobu NAMURA, Hounin KANAYA, Youichi KAWAMURA, Takio OHKA, Hiroshi KURUMAYA, Masahide YASUI, Masaki FUJIMURA, Tamotsu MATSUDA

Author information

Haruhiko OGAWA
The Departments of Internal Medicine, Ishikawa Prefectural Central Hospital
Kazuyoshi KURASHIMA
The Departments of Internal Medicine, Ishikawa Prefectural Central Hospital
Masanobu NAMURA
The Departments of Internal Medicine, Ishikawa Prefectural Central Hospital
Hounin KANAYA
The Departments of Internal Medicine, Ishikawa Prefectural Central Hospital
Youichi KAWAMURA
The Departments of Internal Medicine, Ishikawa Prefectural Central Hospital
Takio OHKA
The Departments of Internal Medicine, Ishikawa Prefectural Central Hospital
Hiroshi KURUMAYA
The Departments of Pathology, Ishikawa Prefectural Central Hospital
Masahide YASUI
The Third Department of Internal Medicine, Kanazawa University School of Medicine
Masaki FUJIMURA
The Third Department of Internal Medicine, Kanazawa University School of Medicine
Tamotsu MATSUDA
The Third Department of Internal Medicine, Kanazawa University School of Medicine

Keywords: Drug-induced pneumonitis, Eosinophilic pneumonia, Respiratory failure, Lymphocyte stimulation test (LST), TBLB, Challenge test

JOURNAL FREE ACCESS

1991 Volume 30 Issue 1 Pages 32-34

DOI https://doi.org/10.2169/internalmedicine1962.30.32

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Abstract

An increasing number of drugs have been implicated in the etiology of eosinophilic pneumonia characterized by the development of pulmonary infiltrates, and peripheral blood eosinophilia. Naproxen is a commonly used nonsteroidal anti-inflammatory drug which may be added to the growing list of pharmacologic agents associated with infiltrative pulmonary lesions. A case of eosinophilic pneumonia induced by Naproxen is described. The results of TBLB, a lymphocyte stimulation test, and a challenge test supported this diagnosis.

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