Hypereosinophilic Syndrome Accompanied with Necrosis of Finger Tips

Mutsuhiro TAKEKAWA; Kohzoh IMAI; Masaaki ADACHI; Shigeo AOKI; Kazuo MAEDA; Yuji HINODA; Akira YACHI

doi:10.2169/internalmedicine.31.1262

Mutsuhiro TAKEKAWA, Kohzoh IMAI, Masaaki ADACHI, Shigeo AOKI, Kazuo MAEDA, Yuji HINODA, Akira YACHI

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Keywords: Churg-Strauss syndrome, eosinophilia, collagen disease, steroid therapy, TNF

JOURNAL FREE ACCESS

1992 Volume 31 Issue 11 Pages 1262-1266

DOI https://doi.org/10.2169/internalmedicine.31.1262

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Abstract

We report a case of hypereosinophilic syndrome (HES) with marked eosinophilia (59.7%) and mononeuritis multiplex (upper limbs and buttocks). Necrosis of the finger tips was the primary manifestation which simultaneously occurred on both sides. These clinical manifestations were improved dramatically by subsequent steroid therapy. Interestingly, an elevation of serum tumor necrosis factor (TNF) was observed. These findings suggest that TNF may play a role in the etiology of necrosis of the finger tips.
(Internal Medicine 31 : 1262-1266, 1992)

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