Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Two Fatal Cases of Hepatitis B Virus Carriers after Corticosteroid Therapy for Bronchial Asthma
Yuriko KOGARyukichi KUMASHIROKiyoshi YASUMOTOSatoshi SHAKADONoriyuki ONOHideya NOGUCHIKazuyoshi NAGATAMichio SATAHirohiko ABENobuo KAKUKyuichi TANIKAWA
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1992 Volume 31 Issue 2 Pages 208-213

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Abstract

We report two hepatitis B virus (HBV) carriers who had liver failure after withdrawal of corticosteroids (steroids) administered for treatment of serious asthmatic attacks. Liver functions deteriorated 1 to 2 wk after withdrawal of the steroid therapy and liver failure occurred. Steroid readministration and intensive therapy for liver failure did not prevent death. An excessive immune response provoked by steroid withdrawal and decreased reserve capacity due to underlying chronic liver disease were thought to be factors in the liver failure. Caution must be exercised in the administration of steroids to patients with underlying chronic HBV infection to prevent exacerbation of hepatitis. Prompt readministration of steroids is indicated if evidence of liver failure develops.
(Internal Medicine 31 : 208-213, 1992)

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© The Japanese Society of Internal Medicine
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