Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Adrenal Myelolipoma Associated with Congenital Adrenal 21-Hydroxylase Deficiency
Chika MURAKAMIMiyuki ISHIBASHIMasahiro KONDOSumako OHSHIROMutsumi FUJITAShigenobu SATOMakoto KAKOHisashi FURUEKunio MIZUGUCHITohru YAMAJI
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1992 Volume 31 Issue 6 Pages 803-806

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Abstract

The occurrence of adrenal myelolipomas is reported in an untreated patient with congenital adrenal 21-hydroxylase deficiency. Laparotomy demonstrated the presence of two lesions, a large tumor which arose from an ectopic adrenal cortex and a smaller tumor in the left adrenal gland. Six cases of adrenal myelolipomas and congenital adrenal hyperplasia have been reported in the literature. All patients were associated with excessive ACTH secretion for a long period of time. The relative frequency of this association, coupled with the observation by Selye and Stone (Am J Pathol 26 : 211, 1950) that anterior pituitary extracts cause myelolipomatous changes in rats, may indicate a possible role for ACTH in the development of myelolipomas.
(Internal Medicine 31 : 803-806, 1992)

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© The Japanese Society of Internal Medicine
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