Acquisition of CD13 and CD33 Expression at Relapse on Acute Myeloid Leukemia Cells with an Unusual Phenotype: MPO+CD13-CD33-

Hiroshi KAWADA; Yukinobu ICHIKAWA; Nobumasa KOBAYASHI; Ryuki FUKUDA; Shuji YONEKURA; Tadami NAGAO

doi:10.2169/internalmedicine.32.733

Acquisition of CD13 and CD33 Expression at Relapse on Acute Myeloid Leukemia Cells with an Unusual Phenotype: MPO⁺CD13^-CD33^-

Hiroshi KAWADA, Yukinobu ICHIKAWA, Nobumasa KOBAYASHI, Ryuki FUKUDA, Shuji YONEKURA, Tadami NAGAO

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Keywords: flow cytometry, phenotypic change

JOURNAL FREE ACCESS

1993 Volume 32 Issue 9 Pages 733-736

DOI https://doi.org/10.2169/internalmedicine.32.733

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Abstract

A case of acute myeloid leukemia (AML)with an unusual phenotype which was negative for a panel of myeloid antigens determined by flow cytometry, but was strongly positive for myeloperoxidase has recently been reported. We herein describe a case of AML with this unusual phenotype at diagnosis; relapse occurred with the acquisition of CD13 and CD33 expressions. Morphological features of the blasts at relapse seemed to be more compatible with myeloblasts than those at diagnosis. These phenotypic and morphological changes are suggestive of asynchronous differentiation, clonal evolution or clonal change of leukemic cells.
(Internal Medicine 32: 733-736, 1993)

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