Bleeding Tendency Caused by the Deposit of Amyloid Substance in the Perivascular Region

Yoshiaki HOSHINO; Kiyohiko HATAKE; Kazuo MUROI; Saburo TSUNODA; Toshiyuki SUZUKI; Akiyoshi MIWA; Shinobu SAKAMOTO; Yasusada MIURA

doi:10.2169/internalmedicine.32.879

Yoshiaki HOSHINO, Kiyohiko HATAKE, Kazuo MUROI, Saburo TSUNODA, Toshiyuki SUZUKI, Akiyoshi MIWA, Shinobu SAKAMOTO, Yasusada MIURA

Author information

Yoshiaki HOSHINO
the Division of Hematology, the Department of Medicine, Jichi Medical School
Kiyohiko HATAKE
the Division of Hematology, the Department of Medicine, Jichi Medical School
Kazuo MUROI
the Division of Hematology, the Department of Medicine, Jichi Medical School
Saburo TSUNODA
the Division of Hematology, the Department of Medicine, Jichi Medical School
Toshiyuki SUZUKI
the Division of Hematology, the Department of Medicine, Jichi Medical School
Akiyoshi MIWA
the Division of Hematology, the Department of Medicine, Jichi Medical School
Shinobu SAKAMOTO
the Division of Hematology, the Department of Medicine, Jichi Medical School
Yasusada MIURA
the Division of Hematology, the Department of Medicine, Jichi Medical School

Keywords: multiple myeloma, amyloidosis, hemostatic agent

JOURNAL FREE ACCESS

1993 Volume 32 Issue 11 Pages 879-881

DOI https://doi.org/10.2169/internalmedicine.32.879

Details

Abstract

A 55-year-old woman, who had systemic amyloidosis associated with multiple myeloma, had sudden development of hematomas of her lip and upper eye lid. There was no evidence of deterioration of multiple myeloma, thrombocytopenia nor deficiency of coagulation factors. Biopsy specimen showed the deposit of amyloid substance in the dermis and perivascular region. The bleeding tendency in this patient with myeloma was likely due to the deposit of amyloid substance in the vascular wall; improvement was achieved with administration of hemostatic agents.
(Internal Medicine 32: 879-881-1993)

Corresponding author

Register with J-STAGE for free!