Acquired Amegakaryocytic Thrombocytopenic Purpura with Humoral Inhibitory Factor for Megakaryocyte Colony Formation

Miyuki KATAI; Toru AIZAWA; Noriko OHARA; Kunihide HIRAMATSU; Kiyoshi HASHIZUME; Takashi YAMADA; Kiyoshi KITANO; Hiroshi SAITO; Toshio SHINODA; Shunji WAKATA; Tatsutoshi NAKAHATA

doi:10.2169/internalmedicine.33.147

Miyuki KATAI, Toru AIZAWA, Noriko OHARA, Kunihide HIRAMATSU, Kiyoshi HASHIZUME, Takashi YAMADA, Kiyoshi KITANO, Hiroshi SAITO, Toshio SHINODA, Shunji WAKATA, Tatsutoshi NAKAHATA

Author information

Miyuki KATAI
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
Toru AIZAWA
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
Noriko OHARA
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
Kunihide HIRAMATSU
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
Kiyoshi HASHIZUME
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
Takashi YAMADA
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
Kiyoshi KITANO
The Department of Second Internal Medicine, Shinshu University School of Medicine
Hiroshi SAITO
The Department of Second Internal Medicine, Shinshu University School of Medicine
Toshio SHINODA
The Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine
Shunji WAKATA
Wakata Clinic
Tatsutoshi NAKAHATA
The Department of Pediatrics, Shinshu University School of Medicine

Keywords: AATP, megakaryocyte colony formation, cyclosporine, prednisolone

JOURNAL FREE ACCESS

1994 Volume 33 Issue 3 Pages 147-149

DOI https://doi.org/10.2169/internalmedicine.33.147

Details

Abstract

A 67-year-old man with thrombocytopenia, and amegakaryocytic but otherwise normal bone marrow, was evaluated. Antibody against thrombocytes was negative and the half-life of thrombocytes was normal. In vitro clonal culture of the patient's bone marrow cells yielded no megakaryocyte colony with normal granulocyte-macrophage and erythroid colony formation. Megakaryocyte colony formation of the control bone marrow cells was significantly suppressed by the addition of the patient's serum to the culture, suggesting the existence of humoral inhibitory factor(s) for megakaryocyte colony formation. Therapeutic trials with plasma exchange, cyclosporine, prednisolone, and cyclosporine plus prednisolone were all unsuccessful, but serious bleeding has been absent.
(Internal Medicine 33:147-149, 1994)

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