Steroid Pulse Therapy in Lupus Cystitis

Chikako SEGAWA; Takashi WADA; Kengo FURUICHI; Kazuya TAKASAWA; Hitoshi YOKOYAMA; Ken-ichi KOBAYASHI

doi:10.2169/internalmedicine.35.155

Chikako SEGAWA, Takashi WADA, Kengo FURUICHI, Kazuya TAKASAWA, Hitoshi YOKOYAMA, Ken-ichi KOBAYASHI

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Keywords: systemic lupus erythematosus (SLE), interleukin-8 (IL-8), monocyte chemotactic and activating factor (MCAF), chemokine, methylprednisolone pulse therapy

JOURNAL FREE ACCESS

1996 Volume 35 Issue 2 Pages 155-158

DOI https://doi.org/10.2169/internalmedicine.35.155

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Abstract

A middle-aged woman with lupus cystitis showed no other symptoms of lupus vasculitis. Cystoscopic findings revealed mucosal hemorrhage and hyperemia. Histological studies of the bladder showed mucosal edema, inflammatory cellular infiltration and the deposition of immune complexes along the vessels. She was treated with a combination of intravenous methylprednisolone pulse therapy and oral prednisolone. Cystoscopy and histological findings showed appreciable improvement. Elevated urinary levels of chemokines such as interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF) decreased during convalescence. These results suggest that the early diagnosis and treatment with steroid pulse therapy achieves improvement of an unusual vasculitis symptom, lupus cystitis.
(Internal Medicine 35: 155-158, 1996)

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