Brain Metastasis in Malignant Pleural Mesothelioma

Akinobu KAWAI; Yukio NAGASAKA; Masato MURAKI; Masahiro FUKUOKA; Takao SATOU; Masatomo KIMURA; Shigeo HASHIMOTO

doi:10.2169/internalmedicine.36.591

Akinobu KAWAI, Yukio NAGASAKA, Masato MURAKI, Masahiro FUKUOKA, Takao SATOU, Masatomo KIMURA, Shigeo HASHIMOTO

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Keywords: asbestos-related pulmonary disease, the syndrome of inappropriate secretion of antidiuretic hormone, ferruginous body, pleural disease

JOURNAL FREE ACCESS

1997 Volume 36 Issue 8 Pages 591-594

DOI https://doi.org/10.2169/internalmedicine.36.591

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Abstract

A 55-year-old male who had a remote history of occupational asbestos exposure consulted us because of chest pain. Chest X-ray revealed diffuse pleural thickening and pleural effusion on the right. A diagnosis of malignant mesothelioma, biphasic type was made by needle pleural biopsy. Fourteen months later, the patient died of brain metastasis. At autopsy, malignant mesothelioma of the pleura with metastasis to the brain and bilateral adrenal glands was observed. Brain metastases proven by autopsy are rare in cases of malignant mesothelioma. The ferruginous body count in the lung tissue was 16 per gram of wet weight.
(Internal Medicine 36: 591-594, 1997)

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