Hericium Erinaceum (Yamabushitake) Extract-induced Acute Respiratory Distress Syndrome Monitored by Serum Surfactant Proteins

Munehide NAKATSUGAWA; Hiroki TAKAHASHI; Chikako TAKEZAWA; Kazutaka NAKAJIMA; Kazutoki HARADA; Yoshitaka SUGAWARA; Shuichi KOBAYASHI; Tatsuo KONDO; Shosaku ABE

doi:10.2169/internalmedicine.42.1219

Munehide NAKATSUGAWA, Hiroki TAKAHASHI, Chikako TAKEZAWA, Kazutaka NAKAJIMA, Kazutoki HARADA, Yoshitaka SUGAWARA, Shuichi KOBAYASHI, Tatsuo KONDO, Shosaku ABE

Author information

Munehide NAKATSUGAWA
Social Welfare Corporation Hokkaido Social Work Association Obihiro Hospital
Hiroki TAKAHASHI
The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Chikako TAKEZAWA
Social Welfare Corporation Hokkaido Social Work Association Obihiro Hospital
Kazutaka NAKAJIMA
Social Welfare Corporation Hokkaido Social Work Association Obihiro Hospital
Kazutoki HARADA
The Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Yoshitaka SUGAWARA
Kyowakai Obihiro Respiratory Hospital
Shuichi KOBAYASHI
Kyowakai Obihiro Respiratory Hospital
Tatsuo KONDO
Kyowakai Obihiro Respiratory Hospital
Shosaku ABE
The Third Department of Internal Medicine, Sapporo Medical University School of Medicine

Keywords: Hericium erinaceum, Yamabushitake, diet food, acute respiratory distress syndrome, surfactant protein A, surfactant protein D

JOURNAL FREE ACCESS

2003 Volume 42 Issue 12 Pages 1219-1222

DOI https://doi.org/10.2169/internalmedicine.42.1219

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Abstract

This is the first report suggesting a causal relationship between acute respiratory distress syndrome and Hericium erinaceum extract, which is commercialized as a diet food. A 63-year-old man was admitted to our hospital for intensive care of severe acute respiratory failure with diffuse infiltration in both lungs. Bronchoalveolar lavage fluid revealed a high percentage of lymphocytes. Lymphocyte stimulation test showed a strong reactivity against extract formulation of Hericium erinaceum (Yamabushitake), which he had taken four months before onset. He recovered with successful steroid pulse therapy under mechanical ventilation. Concentrations of surfactant protein (SP)-A and SP-D in sera reflected the clinical features.
(Internal Medicine 42: 1219-1222, 2003)

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