Decompensated Hepatitis B Virus-related Cirrhosis Successfully Treated with Lamivudine Allowing Surgery for Hepatocellular Carcinoma

Seiji NAKANISHI; Kojiro MICHITAKA; Teruki MIYAKE; Satoshi HIDAKA; Itaru YOSHINO; Ichiro KONISHI; Hidehito lUCHI; Norio HORIIKE; Morikazu ONJI

doi:10.2169/internalmedicine.42.416

Seiji NAKANISHI, Kojiro MICHITAKA, Teruki MIYAKE, Satoshi HIDAKA, Itaru YOSHINO, Ichiro KONISHI, Hidehito lUCHI, Norio HORIIKE, Morikazu ONJI

Author information

Seiji NAKANISHI
The Third Department of Internal Medicine, Ehime University School of Medicine
Kojiro MICHITAKA
The Third Department of Endoscopy Center, Ehime University School of Medicine
Teruki MIYAKE
The Third Department of Internal Medicine, Ehime University School of Medicine
Satoshi HIDAKA
The Third Department of Internal Medicine, Ehime University School of Medicine
Itaru YOSHINO
The Third Department of Internal Medicine, Ehime University School of Medicine
Ichiro KONISHI
The Third Department of Internal Medicine, Ehime University School of Medicine
Hidehito lUCHI
The Third Department of Internal Medicine, Ehime University School of Medicine
Norio HORIIKE
The Third Department of Internal Medicine, Ehime University School of Medicine
Morikazu ONJI
The Third Department of Internal Medicine, Ehime University School of Medicine

Keywords: hepatitis B virus, lamivudine, hepatocellular carcinoma

JOURNAL FREE ACCESS

2003 Volume 42 Issue 5 Pages 416-420

DOI https://doi.org/10.2169/internalmedicine.42.416

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Abstract

A 39-year-old man was diagnosed with hepatitis B virus-related cirrhosis, and because of hepatic exacerbations with icterus and ascites, he had been repeatedly hospitalized. He was treated with lamivudine. Several months later, his ascites disappeared and his liver function was improved from class C to A according to the Child-Pugh classification. Two years later, one small hepatocellular carcinoma was detected, and he underwent a successful hepatectomy. From this case, we consider lamivudine to be useful for improving hepatic function in decompensated liver cirrhosis type B and lamivudine might enable surgical resection of hepatocellular carcinoma.
(Internal Medicine 42: 416-420, 2003)

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