1993 年 86 巻 8 号 p. 1195-1202
Oxatomide was administered to 78 patients (total 86 ears) with otitis media with effusion for four weeks after myringotomy, and its effectiveness and safety were evaluated. The rate of clinical efficacy was 47.7% (marked effect, 15.1%; moderate effect, 23.3%; slight effect, 9.3%). The appearance of the tympanic membrane was improved in 40.7% of the ears. There was improvement in 34.2% of the ears on the pure tone audiogram and in 36.9% on the tympanogram. A side effect was observed in 1 patient (1.3%), but it was mild and no treatment was required. On the basis of these results, oxatomide was judged to be effective in the treatment of otitis media with effusion.