A 49-year-old man went into deep shock soon after an intravenous injection of Neurotropin^® and was referred to our medical center. He developed cardiac arrest in the ambulance about 7 minutes before arriving at our center. Cardio pulmonary resuscitation was performed for about an hour in the emergency room, but ventricular fibrillation (VF) was sustained. The emergency percutaneous cardio pulmonary support system (PCPS) successfully resuscitated the patient and maintained general circulation. The refractory VF indicated the presense of ischemic heart disease. Coronary angiography (CAG) under PCPS support showed a marked spasm on the proximal site of the coronary arteries. We suggest that the refractory VF was related to the coronary spasm induced by anaphylactic reaction. He was soon weaned from PCPS and discharged without any remaining neurological deficits. Emergency application of PCPS could improve the survival of cardiac arrest.