2002 年 48 巻 2 号 p. 90-93
A case of malignant fibrous histiocytoma (MFH) in the maxilla is reported. The patient, a 60-year-old man, presented with diffuse swelling of upper left side of the gingiva after extraction of 7. An elastic soft mass with a smooth surface (40×32mm) was observed in left upper molar region. There was no swelling or hypoesthesia at the left side of the buccal region. Movable lymph nodes 4 mm in diameter were palpable at both sides of the submandibular region. Panoramic X-ray film showed resorption of alveolar bone at the left upper molar region and of the maxillary tubercle. Waters X-ray film revealed a mass protruding into the left maxillary sinus. Computed tomographic (CT) film showed a round mass in the left maxillary sinus, with destruction of the posterior wall. Under a clinicaldiagnosis of maxillary tumor, biopsy was performed. Histologically, the tumor consisted of spindle cells arranged in a storiform pattern. Therefore, a histological diagnosis of MFH was made. The patient was admitted to our hospital, and preoperative transarterial chemotherapy with adriamycin and dacarbazine (ADIC) was administered. The tumor responded partially. He then received partial maxillectomy. After surgery, general chemotherapy with adriamycin and if osf amide (MAI) was given. No severe side effect was observed. The defect of the left side of the maxilla was covered with a prosthesis. No clinical evidence of recurrence was found 2 years 6 months after discharge.