Environmental Health Sciences Division, National Institute for Environmental Studies Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Environmental Health Sciences Division, National Institute for Environmental Studies
Environmental Health Sciences Division, National Institute for Environmental Studies
Environmental Health Sciences Division, National Institute for Environmental Studies
Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Environmental Health Sciences Division, National Institute for Environmental Studies
Endocrine Disrupters & Dioxin Research Project, National Institute for Environmental Studies
Environmental Health Sciences Division, National Institute for Environmental Studies
2001 Volume 43 Issue 4 Pages 185-190
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Bisphenol-A Affects Spermatogenesis in the Adult Rat Even at a Low Dose: Motoharu SAKAUE, et al. Environmental Health Sciences Division, National Institute for Environmental Studies—Bisphenol-A (BPA), a xenobiotic estrogenic compound widely used as a plastics monomer, has been suspected to have a so-called low dose effect on the reproductive system when administered transplacentally. In the present study, we investigated possible low-dose effects of BPA on spermatogenesis in adult rats. Male rats (13 weeks old; W13) were administrated a daily oral dose of BPA, ranging from 2 ng to 200 mg/kg, for 6 days and examined for testicular weight (TW) and daily sperm production (DSP) at W14 and W18. A BPA dose as low as 20 μg/kg tended to decrease TW and significantly reduced both DSP and the efficiency of spermatogenesis (DSP per gram testis) at W18, showing that BPA suppressed a normal increase in DSP and TW from W13 to W18. A single administration of 20 μg BPA/kg to W13 rats affected the intensity or mobility of several protein spots in the testicular cytosol fraction as shown by two-dimensional gel electrophoresis analysis. The present study showed that BPA at a low dose affects spermatogenesis in the adult rat. (J Occup Health 2001; 43: 185-190)
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