Interaction of SM-3997 with Serotonin Receptors in Rat Brain

Hiroshi SHIMIZU; Nobuyuki KARAI; Akira HIROSE; Tohru TATSUNO; Hiroyasu TANAKA; Yoshino KUMASAKA; Mitsutaka NAKAMURA

doi:10.1254/jjp.46.311

Hiroshi SHIMIZU, Nobuyuki KARAI, Akira HIROSE, Tohru TATSUNO, Hiroyasu TANAKA, Yoshino KUMASAKA, Mitsutaka NAKAMURA

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JOURNAL FREE ACCESS

1988 Volume 46 Issue 3 Pages 311-314

DOI https://doi.org/10.1254/jjp.46.311

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Abstract

The propensity of SM-3997 to displace ³H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT_1A receptors, low affinity towards dopamine (D₂) and 5-HT₂ receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT_1B and adrenergic receptors. Moreover, SM-3997 facilitated neither ³H-flunitrazepam binding nor ³H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT_1A receptors but not the BZ-GABA receptor complex.

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