This paper reviews some recent work on issues connecting the theories of scientific explanation and confirmation. Beginning with Harman and Hempel and continuing with Salmon, Miller, Pennock and Ruben, I consider different explications of the explanatory relation that could be used in an Inference to the Best Explanation (I.B.E.) confirmation theory. Causal theories of explanation are currently the most promising and I discuss the strengths of an I.B.E. theory based upon an objective "ontic" view of explanation like Salmon's over an "epistemic" causal view such as Miller's. Finally I show how a causal theorist can address two purported weaknesses of the causal approaches that arise from Humean and Sellarsian arguments.