Six New Chalcones from Angelica keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes

Hiromu OHNOGI; Yoko KUDO; Kenichi TAHARA; Katsumi SUGIYAMA; Tatsuji ENOKI; Shoko HAYAMI; Hiroaki SAGAWA; Yuko TANIMURA; Wataru AOI; Yuji NAITO; Ikunoshin KATO; Toshikazu YOSHIKAWA

doi:10.1271/bbb.110976

Food & Nutrition Science Regular Papers

Six New Chalcones from Angelica keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes

Hiromu OHNOGI, Yoko KUDO, Kenichi TAHARA, Katsumi SUGIYAMA, Tatsuji ENOKI, Shoko HAYAMI, Hiroaki SAGAWA, Yuko TANIMURA, Wataru AOI, Yuji NAITO, Ikunoshin KATO, Toshikazu YOSHIKAWA

Author information

Hiromu OHNOGI
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine
Takara Bio Inc.
Yoko KUDO
Takara Bio Inc.
Kenichi TAHARA
Takara Bio Inc.
Katsumi SUGIYAMA
Takara Bio Inc.
Tatsuji ENOKI
Takara Bio Inc.
Shoko HAYAMI
Takara Bio Inc.
Hiroaki SAGAWA
Takara Bio Inc.
Yuko TANIMURA
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine
Wataru AOI
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine
Laboratory of Health Science, Kyoto Prefectural University
Yuji NAITO
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine
Ikunoshin KATO
Takara Bio Inc.
Toshikazu YOSHIKAWA
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine

Keywords: Angelica keiskei, chalcone, adiponectin, adipocyte

JOURNAL FREE ACCESS

2012 Volume 76 Issue 5 Pages 961-966

DOI https://doi.org/10.1271/bbb.110976

View "Advance Publication" version (May 7, 2012).

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Abstract

Angelica keiskei (Ashitaba in Japanese), a traditional herb in Japan, contains abundant prenylated chalcones. It has been reported that the chalcones from A. keiskei showed such bioactivities as anti-bacterial, anti-cancer and anti-diabetic effects. Xanthoangelol, 4-hydroxyderricin and six new chalcones were isolated in this study from an ethanol extract of A. keiskei by octadecyl silyl (ODS) and silica gel chromatography, and identified by 1D- and 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. The chalcones from A. keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome.

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