Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Polymyositis as a Paraneoplastic Syndrome in Cytotoxic Molecule-positive and Epstein-Barr Virus-associated Peripheral T-cell Lymphoma, Not Otherwise Specified
Hiroko Tsunemine, Hayato Maruoka, Hiroshi Akasaka, Kengo Udaka, Kazuyo Yamamoto, Emiko Ishikawa Sakane, Nobuhiro Hiramoto, Kiminari Ito, Taiichi Kodaka, Tomoo Itoh, Takayuki Takahashi
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Keywords: polymyositis, paraneoplastic syndrome, cytotoxic molecule, Epstein-Barr virus, peripheral T-cell lymphoma, not otherwise specified
JOURNAL OPEN ACCESS

2013 Volume 52 Issue 8 Pages 901-905

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Abstract

We encountered a rare case of cytotoxic molecule-positive and Epstein-Barr virus (EBV)-associated peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), which was clinically preceded by polymyositis. A 50-year-old woman with a 4-year history of steroid-refractory polymyositis developed ulcerative skin swelling on her left arm. A diagnosis of cytotoxic molecule (TIA-1)-positive and EBV-associated PTCL-NOS was made on the basis of immunohistochemical and molecular examinations of the biopsied brachial muscle. Combination chemotherapies were ineffective, with a fatal outcome. Reassessment of the biopsy specimens of the muscle taken at the age of 46 years showed that the PTCL was already present, indicating that the polymyositis was likely a paraneoplastic manifestation.

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© 2013 by The Japanese Society of Internal Medicine
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